Enantioselective Synthesis of Aminodiols by Sequential Rh-Catalysed Oxyamination/Kinetic Resolution.

Enantioselective Synthesis of Aminodiols by Sequential Rh-Catalysed Oxyamination/Kinetic Resolution.

Expanding the Substrate Scope of Amidine-Based Catalysis

J. Guasch,. I. Giménez-Nueno, I. Funes-Ardoiz, M. Bernús, M. I. Matheu, F. Maseras, S. Castillón, Y. Díaz
Chem. Eur. J. 2018, 24, 4635-4642.

Regio- and stereoselective oxyamination of dienes through a tandem rhodium catalysed aziridination-nucleophilic opening affords racemic oxazolidinone derivatives, which undergo a kinetic resolution acylation process using ABCs (amidine-based catalysts) achieving s values up to 117. This protocol was applied to the enantioselective synthesis of sphingosine

ISO CERTIFIED

Banner