Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Míriam Salvadó, José J. Reina, Javier Rojo, Sergio Castillón, Omar Boutureira
Chemistry a European Journal, 2017, 23, 15790-15794

Central scaffold topology and carbohydrate density are important features in determining both the binding mechanism and potency of synthetic multivalent, polydisperse vs. monodisperse carbohydrate systems to a model plant toxin (RCA120). We found lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations as determined by surface plasmon resonance (SPR) and dynamic light scattering (DLS).

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