Welcome to SINTCARB! 

Our group aim to provide new answers to some classical problems in connection with the synthesis of oligosaccharides and glycosides and intend also to provide efficient methods for the synthesis of sphingosines, glycosphingolipids and glycoclusters, and tackle a biologically oriented research. In this sense the SINTCARB group has a broad experience in carbohydrate chemistry and also in transition metal catalyzed reactions and asymmetric catalysis.

 

Substrate-Regiocontrolled Synthesis of Enantioenriched Allylic Amines

by Palladium-Catalysed Asymmetric Allylic Amination: Formal Synthesis of Fagomine
S. Soriano, M. Escudero-Casao, M.I. Matheu, Y. Díaz, S. Castillón.
Adv. Synth. Catal 2016, 358, 4057-4066
   

Metal-free and VOC-free O-glycosylation in supercritical carbon dioxide

Adrià Cardona, Omar Boutureira, Sergio Castillón, Yolanda Díaz, M. Isabel Matheu
Green Chemistry
, 2017, 19, 2687-2694. 

 The feasibility of using scCO2 for obtaining glycoconjugates has been demonstrated, performing metal–free glycosylations without VOCs as solvents
   

Enantioselective Formal Synthesis of Nectrisine

using a Palladium-catalyzed Asymmetric Allylic Amination and cross-metathesis as key steps

S. Soriano, M. Azzouz, J. Llaveria, P. Marcé, M. I. Matheu, Y. Díaz, S. Castillón*
J. Org. Chem. 2016, 81, 5217-5221.

A formal enantioselective synthesis of nectrisine, a potent α-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation and cyclization.

   

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