Welcome to SINTCARB! 

Our group aim to provide new answers to some classical problems in connection with the synthesis of oligosaccharides and glycosides and intend also to provide efficient methods for the synthesis of sphingosines, glycosphingolipids and glycoclusters, and tackle a biologically oriented research. In this sense the SINTCARB group has a broad experience in carbohydrate chemistry and also in transition metal catalyzed reactions and asymmetric catalysis.

 

“Chemical Access to D-Sarmentose Units Enables the Total Synthesis of Cardenolide Monoglycoside N-1

 from Nerium oleander"      
 J. Mestre, M.I. Matheu, Y. Díaz, S. Castillón, O. Boutureira
J. Org. Chem.
2017, 82, 3327-3333

   

Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Míriam Salvadó, José J. Reina, Javier Rojo, Sergio Castillón, Omar Boutureira
Chemistry a European Journal, 2017, 23, 15790-15794

Central scaffold topology and carbohydrate density are important features in determining both the binding mechanism and potency of synthetic multivalent, polydisperse vs. monodisperse carbohydrate systems to a model plant toxin (RCA120). We found lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations as determined by surface plasmon resonance (SPR) and dynamic light scattering (DLS).

   

"Oxidative Activation of C-S bonds with an Electropositive Nitrogen Promoter

Enables Orthogonal Glycosylation of Alkyl over Phenyl Thioglycosides"

Annabel Kitowski, Ester Jiménez-Moreno, Miriam Salvadó, Jordi Mestre, Sergio Castillón, Gonzalo Jiménez-Osés, Omar Boutureira, Gonçalo J.L. Bernardes

Org. Lett.
2017, 19, 5490-5493.
   

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