- 3L: Responding to urgent and growing social needs through a novel platform for Telemedicine.
- Sensors for rapid analysis of the nutritional profile of breast milk.
Borràs-Brull, M., Blondeau, P., Riu, J.
Critical Reviews in Analytical Chemistry 2020, in press. Doi: 10.1080/10408347.2020.1718482
Cánovas, R., Blondeau, P., Andrade, F.J.
Biosensors and Bioelectronics 2020, 163 article number 112302. Doi: 10.1016/j.bios.2020.112302
This work presents a novel strategy to control the mixed potential that allows the development of a potentiometric biosensor for the direct detection of glucose in whole, undiluted blood without any sample pretreatment. The accurate measurement of blood sugar levels in a single drop of whole blood with excellent recovery is presented.
Mohamed Bouri, Julio C. Zuaznabar-Gardona, Marta Novell, Pascal Blondeau, Francisco J. Andrade
Electroanalysis 2020, doi: 10.1002/elan.202060285
A filter paper sputtered with a layer of Pt and subsequently coated with a Nafion® membrane is used as working electrode. The mixed potential of the Pt electrode allows the detection of H2O2 generated by the oxidation of galactose in the presence of the galactose oxidase enzyme. This provides a simple and mediator‐free approach method. The system shows sensitivity values of −62.8±9.4 mV/decade of galactose in the range from 0.3 to 31.6 mM, well within the clinical relevant range. MnO2 nanoparticles were added to decrease the interference from ascorbic acid so that validation of the sensor in whole blood samples was performed with good recovery.
The project “WineSens: Novel chemical sensors, artificial intelligence and cloud computing in the wine industry” has been recognized with one of the URV innovation grants: Research to Business, R2B2019.
Jhonattan F. Baez, Matthew Compton, Sylviane Chahrati, Rocío Cánovas, Pascal Blondeau, Francisco J. Andrade
Analytica Chimica Acta 2020, 1097(8) 204-213, doi: 10.1016/j.aca.2019.11.018
The use of a Pt electrode coated with a layer of Nafion has been described in previous works as an attractive way to perform the potentiometric detection of hydrogen peroxide. Despite the attractive features of this approach, the nature of the non-Nernstian response of this system was not properly addressed. This work provides a phenomenological view of the problem. A general framework to understand the factors that affect the potentiometric response is provided. Experimental evidence showing that the use of polyelectrolyte coatings are a powerful way to control the mixed potential open new ways for the development of robust and simple potentiometric sensors.
Marta Novell, Nayra Rico, Pascal Blondeau, Miquel Blasco, Adrià Maceira, José Luis Bedini, Francisco Javier Andrade, Francesc Maduell
Letter to the editor in Nefrología, doi: 10.1016/j.nefro.2019.06.002
Determination of potassium levels in serum is routinely performed in clinical labs, as it is a critical parameter and abnormal potassium concentrations may lead to fatal cardiac consequences. An immediate test for determination of blood potassium may contribute to prevent such critical issues, for example, arrhythmias. Therefore we have developed and tested a novel point-of-care (POC) device that provides a simple and highly affordable way of measuring potassium levels in a single drop of blood outside the clinical laboratory. This POC device has demonstrated a good correlation with the reference method, proving that it can be an alternative for specific situations where an immediate response is required.
Miguel M. Erenas, Inmaculada Ortiz-Gómez, Ignacio de Orbe-Payá, Daniel Hernández-Alonso, Pablo Ballester, Pascal Blondeau, Francisco J. Andrade, Alfonso Salinas-Castillo, and Luis Fermín Capitán-Vallvey
ACS Sensors 2019, 4, 421-426
An optical disposable sensor for monitoring creatinine levels in urine is described in this paper. The new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10−5 to 1 × 10−2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements, providing a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffe’s reaction.
The research group has obtained one of the URV’s knowledge valorization funds (URV R2B) with the project ‘Sensors, smartphones and cloud: A seamless platform for healthcare’